Pharmaceuticals are usually formulated in the crystalline state for obvious reasons of stability. They may also exist in a disordered and less cohesive state i.e. amorphous offering an interesting alternative route since it offers greater solubility. The amorphous state can be produced by many different techniques : quench from the melt, grinding or freeze-drying. Although the characterization of amorphous pharmaceuticals has received considerable attention, little is actually known about the amorphisation process itself and the precise physical stresses altering the physical state undertaken during the transformation processes (temperature, pressure, shearing, dehydration). The aim of this research proposal is thus to obtain a clear physical understanding of the transformation mechanisms induced by these different methods by using combined neutron scattering and MD simulations.