We present a planktic oxygen isotopes dataset from marine sediment core MD99-2304.Core MD99-2304 was retrieved from the eastern Fram Strait (77°37'15.6N, 9°56'54E), with a CALYPSO piston corer, from 1348 m water depth during the Marion Dufresne IMAGES 5 expedition (leg MD114) in 1999. Measurements were done on the planktic foraminifera species Neogloboquadrina pachyderma, in FARLAB at the Department of Earth Sciences, University of Bergen, using a MAT253 mass spectrometer coupled to a Kiel IV preparation line. Measurements were done between year 2022 and 2025. Results are calibrated to Vienna Pee Dee Belemnite (VPDB) using NBS 19 and NBS 18 and Carrara Marble (CM12) as a working standard. The results provide information on subsurface water mass characteristics in the eastern Fram Strait.