The European cities experimented, during the 20th century, industrialization processes and agricultural changes that triggered the rural-urban exodus. A mostly young population left their rural territories work in cities. These massive migratory movements were the catalyst for the situation of depopulation and aging that currently suffer many rural regions of Europe. Spain is one of the European countries most affected by depopulation. The region of Castilla y León, in the northwest of the country, due to its orographic characteristics and the dispersion of its population in a large number of small municipalities, has been and still is especially vulnerable to the loss of inhabitants in favour of large cities, converting a large part of its territory in a good example of demographic desert. Many municipalities suffer physical isolation due to their orographic environment and, additionally, they present also technological isolation resulting from coverage issues in both land lines and mobile networks. The main objective of this study is to priority areas where the improvement of technological infrastructures and services can lead to reverse or stop the current depopulation trend, at a time when teleworking can be an important lifeline for many rural municipalities.