Bivalves carbon and nitrogen elemental and isotopic ratios (δ13C, δ15N, C and N%, C:N) times series (1981-2021) from 33 sites in France. Bivalve species are the Pacific oyster Crassostrea gigas, and the mussels Mytilus edulis and Mytilus galloprovincialis. This extensive dataset offers a comprehensive view spanning multiple decades and ecosystems, allowing to track how coastal ecosystems and marine species record changing climate, physical-chemical environments and organic matter cycles. This dataset may also be used to study bivalve physiology. Additionally, these data are crucial for establishing isotope baselines for studying food webs. Ultimately, this data set provide valuable information for more effective ecosystem conservation and management strategies in our rapidly changing world.