This proposal aims to provide an atomistic understanding of the adsorption of chiral amino acids and sugars on mineral surfaces using isotopically labelled reagents. Our previous work on LOQ and on D16 at ILL shows that amino acid adsorption affects clay swelling sensitively with chiral selectivity of L- over D-histidine (2011a). We have also shown lysine has opposite chiral selectivity from histidine (2011b). We have now (April 2011) carried out our first runs on NIMROD using both D- and N-15 enriched histidine. The data show that measurable differences in the scattering from the adsorbed enriched and unenriched amino acids are obtained. We now wish to determine the atomic coordinates of lysine and the important DNA sugar ribose in the clay interlayer region. The research will provide new information on chiral selectivity and self-organization of biomolecules on clay surfaces.