Neutron diffraction of fully deuterated amorphous calcium phosphate (d-ACP)

DOI

Bone growth involves the formation of hydroxyapatite, HA, nanocrystals in the body. In vitro studies showed that HA does not precipitate directly, but that amorphous calcium phosphate, ACP, is a precursor of biological HA. Stable synthetic ACP can be consistently prepared using standard methods, such as mixing solutions of ammonium phosphate and Ca chloride, and is found to have a composition of Ca3(PO4)2¿5H2O¿CO2 including structural water. We previously carried out a study of ACP after heat treatment up to 450°C to reduce the proton content. That study included neutron diffraction measured on SANDALS. A key scientific goal remains to study pristine ACP which has not been heat treated. We would like to repeat the experiment, using a new approach to obtain a fully deuterated sample of pristine ACP.

Identifier
DOI https://doi.org/10.5286/ISIS.E.47623838
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/47623838
Provenance
Creator Mr Glyn Cobourne; Dr Gavin Mountjoy; Dr Juan Diego Rodriguez-Blanco; Dr Alex Hannon
Publisher ISIS Neutron and Muon Source
Publication Year 2017
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2014-03-13T00:00:00Z
Temporal Coverage End 2014-03-17T13:45:22Z