Polymorphism of phenytoin at low temperature

DOI

Phenytoin is a simple organic pharmaceutical material that exhibits a phase transition at low temperature to a new phase. The high temperature form exhibits some unusual behaviour whereby the systematic absences suggest a higher symmetry phase than is actually observed. On cooling below 190 K the crystal structure changes to a larger cell where the molecules show modulation along the long axis. Initial single crystal X-ray studies have suggested a number of novel unit cells but the best fitting cell is extremely large (a = 13 b = 43 c = 15). Unfortunately a large portion of the data are below 2 sigma in intensity. It is anticipated that an experiment at HRPD will provide further evidence for this new phase and allow its full characterisation.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24089252
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24089252
Provenance
Creator Dr Alastair Florence; Dr Iain Oswald
Publisher ISIS Neutron and Muon Source
Publication Year 2015
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2012-07-30T08:15:22Z
Temporal Coverage End 2012-11-23T13:50:34Z