The Northern and Southern Patagonian Icefields (NPI and SPI), situated to the north of 52° S, represent the largest glacial systems in South America with surface areas of 4,000 and 12,000 km2, respectively. A smaller icefield covers the Cordillera Darwin (CD, 2600 km²) in the south-western part of the Tierra del Fuego main island. The Gran Campo Nevado (GCN, 200 km²) is situated halfway between SPI and CD. The data sets represents the ice-mass change time series for this four ice accumulation in Southern Patagonia, derived from a regional inversion of GRACE and GRACE Follow-On Level-2 satellite gravimetry data between April 2002 and April 2024.