Cyclic peptide-polymer nanotubes can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. As such, understanding how these systems behave when interacting with a cell membrane is of critical importance. Recently, we have shown that different polymer-peptide compositions have very different cell-uptake properties, whilst remaining non-toxic. Here we wish to study how different conjugates interact with a lipid bilayer and understand the kinetics and mechanisms of these interactions. Using this information we can develop a more novel range of cyclic peptide nanotubes with the goal of designing systems able to readily assemble and disassembly in the cell membrane without any adverse toxicity effects.