Deep Eutectic Solvents (DES) are mixtures of organic salts and hydrogen bond donors, that form strongly hydrogen-bonded room temperature ionic liquids (ILs). DES share many features with ILs (ie. tunable physicochemical properties) which makes them viable green solvents that are less toxic than typical ILs. DES can also be prepared from components which are present in cells, and it has been proposed that they might be one mechanism by which cells can survive in the absence of water, as the DES provides a liquid in which proteins and lipids can retain their function. We are currently investigating the behaviour of amphiphiles with biological interest in DES in order to expand our understanding of the interactions between surfactants with different headgroups and these novel solvents. Here we wish to compare sulfobetaine and phosphocholine headgroup surfactant self assembly in DES.