This data set consist of CTD data collected on board the RV Pelagia during cruise 64PE431. This cruise started in Oranjestad, Aruba on 4 February 2018 and ended in Phillipsburg, Sint Maarten on 11 February 2018. The cruise consisted of a survey across the Caribbean Sea, with hydrographic stations performed between the 1200 m isobath north of Aruba to the 800 m isobaths just south of the Dominican Republic. The aim of these measurements was to document the background hydrography of the Caribbean Sea as well as the hydrographic and velocity structure of a Caribbean anticyclone. A large anticyclone was detected north of Aruba with the use of altimetry field before the start of the cruise. The CTD station positions were adjusted in order to transect the center of this anticyclone. Furthermore four Argo floats provided by the European Argo program were deployed at hydrographic stations. Details on the floatnumbers can be found in the cruise report.