Intercalation of Ciprofloxacin into Lithium - Fluorohectorite at acid and basic pH.


Using quasielastic neutron scattering (QENS) we will investigate the intercalation of Ciprofloxacin (CIPRO) into the synthetic clay Lithium – Fluorohectorite (LiFh) to understand how the pH of the solution during the drug intercalation influences the process. X-ray experiments performed at room indicated that the drug intercalation is strongly related to the pH. In addition, preliminary inelastic neutron scattering results are indicating that the drug intercalation process is changing the water/clay interactions. Using the backscattering spectrometer IRIS we aim to verify how the local dynamics as well as the local environment of the drug molecule is modified when varying the preparation conditions. To achieve our goal we propose to measure the quasielastic spectra at 100 K, 200 K and room temperature of CIPRO, pure LiFh and CIPRO intercalated into LiFh, prepared at acid and basic pH.

Metadata Access
Creator Ms Marcella Berg; Mr Éverton Carvalho dos Santos; Professor Heloisa Nunes Bordallo; Dr Ian Silverwood; Dr Felix Jimenez-Villacorta
Publisher ISIS Neutron and Muon Source
Publication Year 2019
Rights CC-BY Attribution 4.0 International;
OpenAccess true
Contact isisdata(at)
Resource Type Dataset
Discipline Chemistry; Natural Sciences; Physics
Temporal Coverage Begin 2016-10-23T08:00:00Z
Temporal Coverage End 2016-10-28T08:00:00Z