The Mediterranean Sea is a natural laboratory for addressing questions on the formation and evolution of continental margins and the relationship between surface and deep processes. The evaporites deposited during the Messinian Salinity Crisis strongly impact its sedimentary and geomorphology evolution. We present here a compilation of the main regional seismic stratigraphic markers throughout the Central and South Adriatic Sea (CAB and SAB). The following original (uninterpolated) interpretations are provided in xyz format (z in second twt): i) Top of the Mesozoic formation, ii) Base and Top of the Gessoso Solfifera along the CAB, iii) Base and Top of the MSC detrital formation along the SAB, iv) Top of the Upper Unit, v) Base and Top of the middle Pliocene unit, vi) Seafloor. The available reflection seismic dataset the data set is compiled of processed vintage seismic profiles from the Videpi database.