This dataset compiles sex-specific survival, fecundity, and physiological data of the marine calanoid copepod Acartia tonsa following a five-day exposure period to the isolated and combined effects of hypoxia and marine heatwave events, in a laboratory set-up. In more detail, the data bundle includes: 1) Daily measurement of the physico-chemical parameters of the seawater for each aquarium holding the copepods during the five-day exposure period, 2) Sex-specific survival data corresponding to the percentage of females and males alive at the end of the five-day exposure period, 3) Total fecundity at the end of the five-day exposure period, represented by the total number of offspring spawned by all females reared in an aquarium, 4) Sex-specific physiological data, in which routine metabolic rates (individual and specific), upper thermal limit, length, and dry weight are reported, following the five days exposure period to the isolated and combined effects of hypoxia and marine heatwave events.

The experiment was conducted in the Marine Ecological and Evolutionary Physiology Laboratory (MEEP) at the University of Quebec in Rimouski (UQAR), Rimouski, QC, Canada. Copepods were maintained following the stock culture culturing protocol described in Dam et al. 2021 (https://doi.org/10.1038/s41558-021-01131-5). Namely, approximately 200 copepods were kept in three 5 L aquaria filled with artificial seawater kept at a salinity of 28.4 ± 0.5. The physicochemical parameters of the seawater were the following: temperature of 18 ± 0.4 °C, oxygen saturation of 93.7 ± 6.0 %, pH NBS of 8.20 ± 0.09. The photoperiod was kept at 13h light: 11 h dark. Copepods were fed ad libitum with a mixture of three phytoplankters: Tetraselmis sp., Thalassiosira weissflogii and Rhodomonas salina.