NASA's Wide-field Infrared Survey Explorer (WISE; Wright et al.2010) mapped the sky at 3.4, 4.6, 12, and 22 um (W1, W2, W3, W4) in 2010 with an angular resolution of 6.1", 6.4", 6.5", & 12.0" in the four bands. WISE achieved 5 sigma point source sensitivities better than 0.08, 0.11, 1 and 6 mJy in unconfused regions on the ecliptic in the four bands. Sensitivity improves toward the ecliptic poles due to denser coverage and lower zodiacal background.The All-Sky Release includes all data taken during the WISE full cryogenic mission phase, 7 January 2010 to 6 August 2010, that were processed with improved calibrations and reduction algorithms. Original acknowledgement for data: This Progressive Survey distribution makes use of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory/California Institute of Technology, and NEOWISE, which is a project of the Jet Propulsion Laboratory/California Institute of Technology.WISE and NEOWISE are funded by the National Aeronautics and Space Administration.