The liver's proteomics data obtained from Holstein cows treated with abomasal infusions of coconut oil (CTRL) or a mixture of essential fatty acids and conjugated linoleic acids at days -21, +1, +28, and +63 relative to calving. The file contains protein descriptions, raw intensities, associated gene names, peptide count, differentially abundant proteins, and Gene Ontology (GO) and functional enrichment analysis.