Phage defense mechanism and genome editing using novel retrons sourced from isolated environmental bacteria

Retrons are reverse transcription systems that bacteria use to defend against phage predation. To better understand retron biology and the diversity of retrons in the environment, six novel retrons were isolated from their host bacteria in environmental soil/water samples. We characterized the operons of these retrons and tested their ability to defend against a panel of E. coli phages. For two of these retrons, we further unraveled the mechanism of defense by identifying the phage genes responsible for triggering the system. Finally, we also engineered our novel retrons to serve as tools for gene editing (retron recombineering) and benchmarked their efficiency in editing a site on the E. coli genome.

Identifier
Source https://data.blue-cloud.org/search-details?step=~0125BE09D7A83CF2CDC63C462A5234990E884AD5722
Metadata Access https://data.blue-cloud.org/api/collections/5BE09D7A83CF2CDC63C462A5234990E884AD5722
Provenance
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2025
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Coverage Begin 2023-07-01T00:00:00Z
Temporal Coverage End 2024-10-01T00:00:00Z