This dataset contains the CTD data collected during the GOMBESSA 5 cruise, from 1 to 25 July 2019, in the western Mediterranean, jointly by the Andromède océanologie (France) and MARBEC MARine Biodiversity, Exploitation and Conservation (France) teams in the framework of the MEGAFAUNA research project. The full-depth CTD profiles were performed using an autonomous SeaBird SBE 19plus V2 SeaCAT Profiler CTD, from the Zembra vessel belonging to Andromède océanologie (France). 15 stations, from the depth of 200 m to the surface, were sampled off the French and Monegasque coasts (western Mediterranean basin) between latitude 43.06-43.69 °N and longitude 5.65-7.31 °E. The accuracy, specified by the manufacturer, were ± 0.005 °C for temperature and ± 0.0005 S/m for conductivity. The dataset is provided as an ODV (Ocean Data View) collection, which contains, for each station the following parameters: - Depth [salt_water,m] - Temperature [ITS-90,deg-C] - pH - Salinity [PSU] - Conductivity [S/m] - Density [kg/m^3] - Oxygen [mL/L] - Oxygen_sat [% saturation] - Oxygen_umoll [umol/L] - Turbidity [NTU] - Fluorescence [mg/m^3] - Light [PAR/Irradiance] The ZIP archives contain 1/ a map of stations 2/ the list of the ID stations and geographic coordinates 3/ all raw data acquired, for all parameters, in ODV format, 4/ in NetCDF format, 5/ in CSV format and 6/ one vertical profile graph of the Sea Water Temperature for each station. All data acquired are publicly accessible without any restriction (under CC-BY licence). The extracted data are accessible from this GOMBESSA 5 landing page with a downloadable ZIP file.