The data are from sediments collected during the ODP Expedition 112 borehole 680A at the Peruvian Margin. It contains Al (mg/g), Fe (mg/g), Mn (mg/g), P (mg/g), Mo (µg/g), U (µg/g), N (%), S (%), TOC (%), Fe extracted by Na acetate (%), Fe extracted by Na dithionite (%), Fe extracted by ammonium oxalate (%), Fe in pyrite, δ15N (‰), δ13C (‰) in the organic fraction of sediments and δ98Mo (‰) data from 45 different samples. The goal of collecting these data was to investigate how the oxygen levels of the seafloor and water column fluctuated from the Pliocene to the Holocene.