49 datasets found

In this data repository, we have uploaded the Supplementary Information of Chapter 3-6 of the thesis “The many faces of regeneration: Engineering multifunctional scaffolds for...

Biomineralized collagen with intrafibrillar calcium phosphate mineral provides an excellent mimic of the composition and structure of the extracellular matrix of bone, from...

This dataset is part of a bachelor thesis work, focusing on the annotation of emotional and sentiment content in literary translations. It involves the annotation of excerpts...

The native extracellular matrix (ECM) undergoes constant remodelling, where adhesive ligand presentation changes over time and in space to control stem cell function. As such,...

Large segmental osseous defects heal poorly, creating major medical, social and economic issues. Although several clinical options for healing such defects exist, all have major...

This file contains the supporting information for Chapter V-I – “Biomimetic double network hydrogels: Combining dynamic and static crosslinks to enable biofabrication and...

Calcium phosphates (CaPs) are extensively used as biomaterials for bone repair and regeneration and are considered an interesting synthetic alternative for natural bone grafts....

We previously found that surface topographies induce the expression of the Scxa gene, encoding Scleraxis in tenocytes. Because Scxa is a TGF-β responsive gene, we investigated...

In recent years, synthetic calcium phosphate (CaP) ceramics have emerged as an alternative to bone grafts in the treatment of large critical-sized bone defects. In order to...

Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression, and cell identity, surface topography...

In this data repository, we have included the Supplementary Data of Chapters 3–7 of the associated dissertation (Cartilage and Bone in Concert: Biofunctional Scaffolds for...

Dynamic hydrogels are attractive platforms for tissue engineering and regenerative medicine, due to their ability to mimic key extracellular (ECM) mechanical properties like...

Bone morphogenetic proteins -2 and -7 (BMP-2 and BMP-7) are effective in treating large bone defects, but the required doses are high, resulting in side effects and elevated...

The field of human induced pluripotent stem cells (hiPSCs) has seen significant progress since the discovery of reprogramming somatic cells using the transcription factors Oct4,...

Introduction Two known multiple trauma treatment principles are Early Total Care (ETC), and Damage Control Orthopedics (DCO). Cellular mechanisms that underlie the connection...

This file contains the supporting information for Chapter IV – “Tuning hydrogels by mixing dynamic crosslinkers: enabling cell-instructive hydrogels and advanced bioinks”

Corneal diseases, a leading cause of global vision impairment, present challenges in treatment due to corneal tissue donor scarcity and transplant rejection. Hydrogel...

Hydrogels designed using dynamic (reversible) chemistry are prominent tools in diverse research areas as they grant access to time-dependent mechanical properties (self-healing,...

Biomineralized collagen, consisting of fibrillary type-I collagen with embedded hydroxyapatite mineral, is a bone-mimicking material with potential application as a bone graft...

Pancreatic beta cells have inadequate levels of antioxidant enzymes, and the damage induced by oxidative stress poses a challenge for their use in a therapy for patients with...