Hydrogen-bonding is a key fundamental parameter in self-assembly of amphiphiles, driving aggregation via the hydrophobic effect. H-bonding rich non-aqueous solvents are of interest as they are analogous to water, the archetypal solvent with a dense hydrogen bonded network. Non-aqueous solvents can provide advantages, such as high boiling points and excellent solvency for organic molecules. However, self-assembly in H-bonding rich non-aqueous solvents is not well understood. Here, in collaboration with the GSK Oral Health Division, we propose a small-angle neutron scattering study (SANS) of self-assembled structures formed by surfactants in several H-bonding rich non-aqueous solvents, including ethylene glycol, propane-1,3-diol and propylene glycol, which vary in the H-bonding number and density. We will vary surfactant architecture, concentration and propose to investigate temperature.