Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation or crosslinking resulting in lack of orientation and loss of activity. Using an enzyme mediated conjugation method we have prepared well-defined protein-polymer conjugates using a model protein, green fluorescent protein (eGFP) with diblock copolymers based on several hydrophilic-hydrophobic biocompatible copolymers. In this proposal, we wish to analyse the copolymers alone and to probe eGFP-copolymer conjugates to get a clearer picture of the influence of the molecular weight on morphologies, phase behaviour and order-disorder transitions.