Metabolomic and proteomic profiling of peripheral blood exosomes in amyotrophic lateral sclerosis

DOI

Metabolomic and proteomic profiling of exosome from 9 healthy subjects and 9 patients diagnosed with amyotrophic lateral sclerosis are shared (ALS). Serum EVs were obtained from subjects included in the protocol METABOMU (NCT02670226). Proteomics and metabolipidomics analyses were performed following EVs purification through Size Exclusion Chromatography and characterization by Nanoparticle Tracking Analysis (NTA). Proteomics (LC-MS/MS followed by TimsTOF Pro Mass Spectrometer), metabobolipidomics (Q-Exactive mass spectrometer).

Identifier
DOI https://doi.org/10.57745/OCOFBI
Related Identifier IsCitedBy https://doi.org/10.1007/s12031-025-02315-w
Metadata Access https://entrepot.recherche.data.gouv.fr/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.57745/OCOFBI
Provenance
Creator Hélène Blasco ORCID logo; Charlotte Veyrat-Dubereix ORCID logo; Antoine Lefebvre ORCID logo; Patrick Emond ORCID logo
Publisher Recherche Data Gouv
Contributor Nicolas Vallet; Hélène Blasco; Yara Al Ojaimi; Philippe Corsia; U1253 Imagerie et Cerveau; Recherche Data Gouv
Publication Year 2024
Funding Reference French Association of amyotrophic lateral sclerosis
Rights etalab 2.0; info:eu-repo/semantics/openAccess; https://spdx.org/licenses/etalab-2.0.html
OpenAccess true
Contact Nicolas Vallet (INSERM); Hélène Blasco (INSERM); Yara Al Ojaimi (Inserm)
Representation
Resource Type Dataset
Format text/tab-separated-values; text/markdown
Size 27944; 385; 8438; 2267
Version 1.1
Discipline Life Sciences; Medicine