Here, we present zircon geochronology and tephra/glass compositions from four explosive Pleistocene eruptions of the Atitlán caldera in Guatemala. Our datasets encompass zircon 238U-230Th disequilibrium, U-Pb, and (U-Th)/He geochronology, analyzed using a CAMECA IMS 1280-HR secondary ion mass spectrometer (SIMS) at Heidelberg University, Germany, alongside noble-gas and inductively coupled plasma mass spectrometry (ICPMS) at Curtin University, Australia. Major and trace element compositions of glass shards were determined through electron microprobe analysis (EMPA) at GEOMAR - Helmholtz Centre for Ocean Research Kiel and by laser ablation ICPMS at the Institute of Earth Sciences, Academia Sinica in Taipei. Whole-rock U-series analyses were carried out using a ThermoFisher Neptune multi-collector ICPMS at the University of Wyoming (UWYO, USA).