The study of porous metal-organic framework (MOF) materials has attracted considerable attention. We seek to develop new stable MOFs for practical gas separation and request 3 days on WISH to study the preferred binding sites of adsorbed gas molecules (SO2 and CO2) within a series of isostructural MOFs (MFM-190, MFM-191 and MFM-192) with varying functional groups. Preliminary results demonstrate remarkable adsorption and selectivity of SO2 for these materials under ambient conditions. The high resolution, low background and large d-spacing capabilities of WISH make it ideal for analysing the precise locations of gas molecules within these porous MOFs and to define the preferred orientations of molecules with respect to the binding sites on the pore surface. This study will reveal key structural insights into the role of the pore environment for gas uptake.