The dataset contains meteorological observations from radiosondes during a measurement campaign with the drone LUCA (Lightweight high Ceiling Aerial System). The measurements were collected between the 25th and the 29th October 2021 at rather erratic launch times, as operations from the military training area Todendorf (Panker) in Northern Germany within the restricted airspace belonging to it depend on air traffic control clearance. As parameters, pressure, temperature, humidity and wind direction/speed were observed along with time and position of the radiosonde. The data allows intercomparing the radiosonde with collocated drone measurements which enables a discussion on the possible use of the drone LUCA and similar systems for operational meteorology.