SLC7A8 coding for LAT2 is associated with early disease progression in osteosarcoma and transports doxorubicin

DOI

Background: Despite (neo)adjuvant chemotherapy with cisplatin, doxorubicin and methotrexate, some patients with primary osteosarcoma progress during first-line systemic treatment and have a poor prognosis. In this study, we investigated whether patients with early disease progression (EDP), are characterized by a distinctive pharmacogenetic profile.Methods and Findings: Germline DNA from 287 Dutch high-grade osteosarcoma patients was genotyped using the DMET Plus array (containing 1,936 genetic markers in 231 drug metabolism and transporter genes). Associations between genetic variants and EPD were assessed using logistic regression models. The datafile (Hurkmans_SumStat_LogReg_DMET_EarlyProgressiveDisaese_CovarMetasSexAge_GRCh37.txt) contains the results of this anaylsis.Conclusions: This study identified a novel locus in SLC7A8 to be associated with EPD in osteosarcoma.

Identifier
DOI https://doi.org/10.17026/dans-2b8-yswb
Metadata Access https://lifesciences.datastations.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.17026/dans-2b8-yswb
Provenance
Creator E.G.E. Hurkmans; J.B. Koenderink; J.M.W. van den Heuvel; Y.M.H. Versleijen-Jonkers; M.H.S. Roeffen; J.M. Groothuismink; H.I. Vos; W.T.A. van der Graaf; U.E. Flucke; G. Muradjan; H.W.B. Schreuder; M.M. Hagleitner; H.G. Brunner; A.J. Gelderblom; A.M. Cleton-Jansen; H.J. Guchelaar; E.S.J.M. de Bont; D.J. Touw; G. Nijhoff; L.C.M. Kremer; H.N. Caron; R. Windsor; A. Patiño-García; A. González-Neira; F. Saletta; G. McCowage; S. Nagabushan; D. Catchpoole; D.M.W.M. te Loo; M.J.H. Coenen
Publisher DANS Data Station Life Sciences
Contributor RU Radboud University
Publication Year 2022
Rights CC BY 4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Contact RU Radboud University
Representation
Resource Type Dataset
Format text/csv; text/xml; text/plain; application/zip; application/octet-stream
Size 192941; 13748; 626; 35138; 14294; 15213; 889114; 9341; 238580
Version 1.0
Discipline Life Sciences; Medicine