Single-centre retrospective observational study including 100 consecutive patients (≥ 16 years) diagnosed with septic shock, according to the 2001 International Sepsis Definition Conference criteria, admitted to our ICU after the institution of a patient-tailored therapy protocol, compared with a historical control group of 100 patients. The patient-tailored therapy protocol included the use of IgM-enriched immunoglobulins for patients with low plasma IgM levels, blood purification strategies for patients with high plasma levels of cytokines or endotoxin, albumin correction and vasoactive agents modulation. Clinical and therapeutic parameters were noted at the time of septic shock diagnosis and for the first 24 hours. The primary outcome was ICU mortality. ICU-mortality was lower in the patient-tailored therapy cohort as compare to the standard therapy cohort (32% versus 57%, p<0.001). An individualised therapeutic approach in septic patients may be associated with a survival benefit.

Date Submitted: 2020-06-23