Molecular pathology reports of patients with colorectal carcinoma were collected from PALGA using specific queries from 1 October 2017 to 30 June 2019 (for details see: Figure 1A PMID: 34675090 / DOI: 10.1136/jclinpath-2021-207865). Manual curation of these reports showed 4060 patients with CRC undergoing predictive mutation analyses in this 21-month study period. Details ofthe mutation analyses (ie, technique, gene panel, diagnostic yield) were manually extracted from these reports and shown in the current dataset.