The present study aims at using simultaneous INS and Raman scattering experiments to elucidate resistance to cisplatin-like Pt(II)- and Pd(II)-based anticancer agents via glutathione detoxification. Drug binding to this endogenous sulfur-containing tripeptide will be investigated, as compared to the major pharmacological target (DNA). Apart from cisplatin, the mono- and polynuclear complexes Pt(dap)Cl2 and Pt2(Spm)Cl4 will be studied, as well as their Pd(II) counterparts. The results thus obtained will be analysed in the light of previously obtained INS and theoretical data for these compounds and for cisplatin´s interplay with DNA, as well as for glutathione competition towards cisplatin-DNA adducts.