How proteins fold from their linear sequence into their functional structures is still not understood and the misfolding of proteins is linked to a variety of diseases - such as Alzheimer's, Huntington's and diabetes. In life, proteins fold in aqueous solution and as such investigation of this process must be assessed in a similar environment. This proposal is part of a programme of work to investigate protein folding in solution using small peptides which adopt a range of conformations in solution. This allows for an assessment of hydration in the folded and unfolded states of a peptide allowing for important details of how hydration contributes to this process to be determined.