Mechanical properties of bio-membranes interacting with a model synovial fluid

DOI

Ultrathin lipid linings are terminal layers on articular cartilage and are of outmost importance for lubrication in mammalian joints. We will apply specular and offspecular neutron scattering to solid-supported, hyaluronic acid (HA)-interlinked DMPC oligo-bilayers against excess aqueous liquid phases (HA+D2O). The experiments will yield valuable insight into the microscopic mechanical behavior of the lipid coatings and thereby into the underlying mechanism responsible for lubrication. We will extract the compression- and bending moduli of the HA-interlinked lipid membranes by adapted modelling of the shape of the recorded Bragg-sheets in two dimensions (qz and q||). With a preset but varied number of lipid bilayers in the stacks we will focus on the influence of HA and temperature on the system mechanics.

Identifier
DOI https://doi.org/10.5291/ILL-DATA.8-02-646
Metadata Access https://data.ill.fr/openaire/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=10.5291/ILL-DATA.8-02-646
Provenance
Creator Kloesgen, Beate; Deme, Bruno; Schneck, Emanuel; Kreuzer, Martin; Dahint, Reiner; Steitz, Roland
Publisher Institut Laue-Langevin
Publication Year 2013
Rights OpenAccess; info:eu-repo/semantics/openAccess
OpenAccess true
Representation
Resource Type Dataset
Size 954 MB
Version 1
Discipline Particles, Nuclei and Fields