The HeidelBAG unifies structural efforts of the EMBL, the Heidelberg University Biochemistry Center (BZH), and the German Cancer Research Center (DKFZ). Central to all projects are large assemblies involved in chromosome organization and transcription control, in nuclear and cytoplasmic RNA regulation, in translational control as ribosome associated factors or further on in protein targeting, membrane protein insertion or post-translational modification. As new members, Mandy Jeske from BZH adds projects on early embryonic development in Drosophila and Erec Stebbins from DKFZ on immune evasion of the African trypanosome T. brucei. Nearly all projects make use of integrated structural biology techniques (MX, SAXS/SANS, NMR, cryo-EM) combined with complementary biophysical, biochemical and cell biological approaches, a strategy that warrantied the continuous success of the BAG. More and more pathological implications of the studied central cellular processes come into focus.