Solid dispersions are molecular mixtures of drug and excipient, usually a polymer. The use of solid dispersions is of interest as a means of improving the rate of solution (i.e. dissolution) and solubility in aqueous solvents of hydrophobic drugs, allowing poorly-water soluble drugs to be successfully administered. We have recently observed that the dissolution rate in water of the poorly-soluble griseofulvin obtained from solid dispersions prepared by spray drying is greatly influenced by the solvent from which it is spray dried. This observation suggests that polymer conformation in the solvent is critical in the preparation of the solid solution as it influences the ability of the polymer to interact with the drug. This study will use SANS, in combination with contrast variation, to determine the effect of solvent and drug on polymer conformation in solution.