This dataset contains sample preparation parameters and stable carbon and oxygen isotope measurements from ODP Site 108-659, located on the Cabo Verde Plateau in the eastern North Atlantic Ocean (18°05'N, 21°02'W; 3070 m water depth). The record spans Marine Isotope Stages 36 to 42 during the Early Pleistocene and includes wet weight, dry weight, coarse fraction weight, and stable isotope data obtained from planktonic and benthic foraminifera. Sediment samples were processed following the standard procedures of the Sedimentology and Micropaleontology Laboratory of the Divisão de Geologia e Georecursos Marinhos (DivGM), Instituto Português do Mar e da Atmosfera (IPMA). Samples were weighed before and after freeze-drying to determine dry weight, washed through a 63 μm sieve, and the coarse fraction was dried and weighed. Stable carbon (δ¹³C) and oxygen (δ¹⁸O) isotope measurements were performed on the planktonic foraminifer Globigerinoides ruber (white) and the benthic foraminifera Cibicidoides wuellerstorfi at the Leibniz Laboratory for Radiometric Dating and Stable Isotope Research (Kiel University, Germany) using a Finnigan MAT 253 mass spectrometer coupled to a Kiel IV carbonate preparation device. Isotope values are reported relative to the Vienna Pee Dee Belemnite (VPDB) standard. The age model is based on correlation of the benthic δ¹⁸O record to the LR04 benthic isotope stack. These data provide a stratigraphic and stable isotope record for ODP Site 108-659 during Marine Isotope Stages 36 to 42.