The HeidelBAG unifies structural efforts of EMBL Heidelberg and the Heidelberg University Biochemistry Center (BZH). Central to all projects are large assemblies involved in chromosome organization and transcription control, in nuclear and cytoplasmic RNA regulation, in translational control by ribosome associated factors or further on in protein targeting, membrane protein insertion or post-translational modification. While Eric Stebbins from DKFZ has left the BAG, Jirka Peschek from BZH will join and adds projects on tRNA ligases and interactors. Nearly all projects make use of integrated structural biology techniques combined with complementary biophysical, biochemical and cell biological approaches, a strategy that warranties the continuous success of the BAG. More and more pathological implications of the studied central cellular processes come into focus. In the 1st year of the proposal the BAG reports on 17 publications and 43 PDB entries and many unpublished results.