Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms. We have examined the effects of atorvastatin, a globally prescribed drug, on the blue mussels - Mytilus edulis. This data set presents the depletion of atorvastatin (ATO) in 18, 25, and 36 L holding tank of blue mussels over 48 h time period.