Transcription-dependent domain-scale 3D genome organization in dinoflagellates

Dinoflagellate chromosomes represent a unique evolutionary experiment, as they exist in a permanently condensed, liquid crystalline state, are not packaged by histones, and contain genes organized into polycistronic arrays, with minimal transcriptional regulation. We analyze the 3D genome of {Breviolum minutum}, and find large topological domains without chromatin loops, demarcated by convergent gene array boundaries (``dinoTADs’’). Transcriptional inhibition degrades dinoTADs, implicating transcription-induced supercoiling as the primary topological force in dinoflagellates. Overall design: Hi-C libraries associated with the project

Identifier
Source https://data.blue-cloud.org/search-details?step=~0124710E7D9FA540E53759D932CE939A4BF454506DC
Metadata Access https://data.blue-cloud.org/api/collections/4710E7D9FA540E53759D932CE939A4BF454506DC
Provenance
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2025
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Coverage Begin 2020-07-10T00:00:00Z
Temporal Coverage End 2021-03-23T00:00:00Z