Agro-waste can be a source of molecules that can find exploitation in different fields. For example, aromatic molecules, such as vanillic acid, can be extracted and exploited as building blocks for the synthesis of new polymeric structures. Indeed, the aromatic ring can confer rigidity to the macromolecular chains and, then, good mechanical properties. In NoAW project the presence of vanillic acid in wine pomace has been revealed, even if the amount of it was too low and the mixture of components too complex to evaluate a separation of the molecules. However, vanillic acid can be found in other biomass or can be derived from vanillin, that is commercially available. Novel copolyesters, based on vanillic acid, have been successfully synthesized and characterized. The synthesis proceeds through a two-steps solvent-less polycondensation and seems suitable for an industrial upscaling. Random copolymers, characterized by the presence of -pentadecalactone as comonomer, are characterized by good thermal stability, a homogeneous amorphous phase and crystal phases that depend on the composition. The crystallization behavior resulted complex and spherulitic morphologies observed. In any case, copolymers present a lower degree of crystallinity with respect to the homopolymers, are processable and filmable. For this reason, they can be considered potential bio-based substitutes of petro-derived aromatic polyesters for packaging applications. The end of life of these materials was not studied yet, but it is expected that strategies of recycling can be successfully applied. In conclusion, the vanillin platform for polymer synthesis is now enriched of new copolymers with tunable properties.