Understanding the role of cement lines for human bone mineralization via XRF/ SAXS and Texture tomography

DOI

Bone is essential for human health and wellbeing due to its central role in the musculoskeletal system. Bone is continually remodeled to maintain bone performance. At the border between old and new bone, cement lines occur. Cement lines are only a few microns across and their composition differs from that of the surrounding bone. However, their structure remains unknown. This information is important for understanding both bone mechanical properties and the signals that govern the behavior of bone cells involved in bone remodeling. Since bone is a 3D composite, the structure must be mapped in 3D. This has recently become possibly by new techniques developed by the proposers. We thus propose to conduct combined SAXS tensor and texture tomography to map the orientation distributions of, respectively, nanostructural features and the bone biomineral nanocrystals. This will enable forming a structural model of cement lines for the first time.

Identifier
DOI https://doi.org/10.15151/ESRF-ES-2093751548
Metadata Access https://icatplus.esrf.fr/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatplus.esrf.fr:inv/2093751548
Provenance
Creator Tilman GRUNEWALD; Moritz STAMMER; Cajetan MAGER; NICOLAS CHARPENTIER ORCID logo; Henrik BIRKEDAL ORCID logo; Anastasiia SADETSKAIA (ORCID: 0000-0003-4344-961X)
Publisher ESRF (European Synchrotron Radiation Facility)
Publication Year 2028
Rights CC-BY-4.0; https://creativecommons.org/licenses/by/4.0
OpenAccess true
Representation
Resource Type Data from large facility measurement; Collection
Discipline Particles, Nuclei and Fields