Datasets produced as a result of analyses on calypso giant gravity core (CASQ) AMD15-CASQ1 and box core (BC) AMD15-CASQ1-BC onboard the CCGS Amundsen ArcticNet 2015 Leg 4a expedition. Marine sediment cores cover the mid-Holocene to present and were recovered in Smith Sound, northernmost Baffin Bay. Discrete subsamples were taken from U-channels for analysis of geochemical, palynological and micropaleontological analysis, with the aim of reconstructing palaeoceanographic conditions in the region of the North Water Polynya.