Aqueous creams are widely used in the treatment of skin conditions like rosacea, dermatitis and psoriasis. They are highly complex chemical mixtures, and our knowledge of their molecular structure, and the relationship between this and their long term stability and clinical benefit to patients is sadly lacking. The investigations to be performed in this study (using the technique of small angle neutron scattering) aim to determine the effect of chemical composition on the internal structure and properties of simple creams prepared according to a British Pharmacopoeial formulation, Through the proposed studies, we hope to gain a better understanding of the molecular structural changes that underlie the observed changes in the viscosity and consistency of the creams that occur on ageing and as the result of including additives like (antimicrobial) preservatives.