Summary statistics of GWAS of cognitive and noncognitve skills as created and used in Demange et al. 2022 "Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores".

If summary statistics are used, please make sure to include a reference to the original manuscript.

For the original summary statistics of Cog and NonCog, including NTR and UKBiobank siblings data, see Demange, P.A., Malanchini, M., Mallard, T.T. et al. Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nat Genet 53, 35–44 (2021). https://doi.org/10.1038/s41588-020-00754-2

NonCog_GWAS: GWAS-by-subtraction of non-cognitive aspects of educational attainment. Compared to Demange et al. 2021 the GWAS is excluding NTR and 23andMe participants, and UKBiobank siblings, adoptees and related individuals Cog_GWAS: GWAS-by-subtraction of cognitive aspects of educational attainment. Compared to Demange et al. 2021 the GWAS is excluding NTR participants and 23andMe participants, and UKBiobank siblings, adoptees and related individuals.

Columns Names: SNP: SNP rs number CHR: chromosome number BP: base pair position A1: effect allele A2: other allele MAF: minor allele frequency in 1000 Genomes Phase 3 Beta: effect of the A1 allele
SE: standard error of Beta Z: Z-statistic P: p-value.

The effective sample sizes were estimated to: NonCog N = 458211 Cog N = 223819