With the recent progress in additive manufacturing (AM), the grain shape and crystallographic orientations can be controlled in laser beam melting (LBM). This is an opportunity to optimize the grain texture of materials to fit with higher load specifications. However, grain texture governs the mechanical fields at the grain scale. So, it is primordial to know how these mechanical fields are modified by the novel texture that it is possible to generate thanks to AM. To do that, the evolution of strain partitioning through grains will be studied with 3DXRD method after different number of fatigue cycles. Furthermore, DCT experiments are an opportunity to create numerical clones of 3D 316L microstructures obtained by AM in order to use it in finite element simulations to predict the areas of fatigue crack initiation. The coupling of these two methods is the key to understand the strain partitioning in AM microstructures and its role on fatigue crack initiation.