On the structure and stability of dinucleotides in aqueous solution

DOI

eoxyribonucleic acids (DNA) encode the genetic information for all living things and some viruses. Remarkably, DNA is only comprised of four unique nucleotides which differ only with respect to their nitrogenous bases (adenine (A), guanine (G), cytosine (C) and thymine(T)), yet all of the information needed for life to evolve is contained within this molecular structure. DNA is an organic polymer where the nucleotides are linked into a backbone by their phosphatedeoxyribose components with the bases protruding in such a way that the two strands can bind together, entwining to form a double helix. Although the solid state polymeric structure of DNA is well known, the structure of this life-giving molecule in aqueous solution in which it functions in vivo remains unclear.

Identifier
DOI https://doi.org/10.5286/ISIS.E.60449158
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/60449158
Provenance
Creator Dr Sylvia McLain; Ms Nicola Steinke; Mr Andrew Johnston; Dr Sam Callear
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2015-04-26T09:00:00Z
Temporal Coverage End 2015-05-01T09:00:00Z