This dataset contains hydrographic measurements collected in Dickson Fjord, Northeast Greenland, on August 14th 2022, as part of the Greenland Gradients research project led by Rysgaard, Søren. The data were collected to address the fate of glacial meltwater and the dynamics between glacier and fjord waters near the terminus of Hisinger Glacier. Measurements were taken using a SonTek CastAway CTD, which was deployed from a drone platform to access areas close to the glacier front that are otherwise difficult to reach. Three vertical temperature and salinity profiles were obtained at distances of 20, 30, and 50 meters from the glacier terminus, covering depths from the surface down to approximately 98 m. The three profiles were collected on 14 August 2022 at 15:04 (Flight 1), 15:58 (Flight 2), and 16:37 (Flight 3) UTC. The data is complementary to shipborne CTD measurements and stable water isotope analyses collected during the same field campaign, which took place from July 31st to August 15th 2022.