Copper is a common aquatic toxicant that is known to impair the olfactory system in fish. Sea lamprey, a species of conservation concern in its native areas of Europe and a detrimental invasive species in North America, rely on olfactory cues to migrate to natal streams and initiate spawning. Manipulating these olfactory-mediated behaviors is a critical component of the conservation and management of this species however, anthropogenic inputs of copper to aquatic habitats have the potential to impede these efforts. To identify the transcriptomic mechanisms of copper-induced olfactory impairment we assay the whole transcriptome of olfactory tissue in lamprey exposed to environmentally relevant concentrations of copper.