Polymer-Lipid Nanodisc Adsorption to the Air-Solution Interface

DOI

Nanodiscs are self-assembled structures composed of phospholipids containing a stabilizing membrane-scaffold protein or, in the case of this proposal, a polymer belt. They are capable of encapsulating single membrane proteins and as such have many potential uses including the delivery of membrane proteins to cell surfaces. In this proposal we wish to study how polymer stabilised nanodiscs interact with air-liquid surfaces. This forms part of a broader investigation looking at how membrane proteins can be delivered to interfaces (including solid-liquid) for incorporation into model membranes or to act as nucleation sites for bulk crystalisation. A first step in this direction is to understand how these discs behave at an interface without the additional complication of proteins. The air-liquid surface presents a convenient interface for these initial studies.

Identifier
DOI https://doi.org/10.5286/ISIS.E.47624617
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/47624617
Provenance
Creator Professor Karen Edler; Dr Gavin Hazell; Dr Thomas Arnold; Miss Helena Coker; Dr Luke Clifton
Publisher ISIS Neutron and Muon Source
Publication Year 2017
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2013-11-22T00:00:00Z
Temporal Coverage End 2014-04-02T23:00:00Z