This study aimed at identification of genetic regulations for desiccation and submergence tolerance in intertidal seaweed species Ulva lactuca which arisies periodically due to tidal rhythms. Overall design: The algal thalli were collected and acclamatised to laboratory. The experiments were designed for desiccation for different durations at a moisture condition of 20%. The thalli were desiccated for 24 h, 36 h and 72 h and investigated for transcriptomics by RNA-seq. After each desiccation time point, the thalli were resubmerged in autoclaved seawater. After 1 h of resubmergence, thalli were collected and processed for RNA extraction and subsequent RNA-seq. The transtion of desiccation to submergence will determine the genetic regulations for submergence tolerance in this group of plants.