In order to obtain genetically engineering strain of Penicillium oxalicum with high Raw Starch Digesting Glucoamylase production,we deleted PoxCxrC and overexpressed POX_f08097 in Penicillium oxalicum TE4-10 ,and we want to investigating the function of deletion of PoxCxrC and overexpression of POX_f08097 at transcriptional level. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of at 24h after tansfer to the enzyme production medium with raw starch (the only carbon source).